I can't imagine them running better than they are now but if they can I'd like to see it!There's literally 3 posts on page 8 (same page you posted on) about the advantages and need to have them tuned properly. Yes they will run not tuned for them. Maybe even better than the previous style. But will run better once tuned.
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but yeah. With these trucks with the versatility of efi live, any small change can be addressed and improved upon. Such as injectors or pumps or turbos. Think of it this way. Let's say you have tunes for a stock turbo. Then you slap on a 63.5 mm cover or a stealth 64. Yes it's gonna run a lot better than it ever has. And make better power. But address that new turbo and new surplus of air, and your truck can make more power and run even smoother with updated tunes. Same with the injectors.